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Some Blonde Scientist

Some Blonde ScientistSome Blonde ScientistSome Blonde Scientist
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The dance of death

In the time it takes you to read this one sentence, ten million cells  within your body would have died through a form of cell death known as  apoptosis. Not only does cell death maintain our body's health, it also underpins the pathogenesis of many diseases and therapeutics. Previously,  we discovered that dying immune cells can undergo an explosive process we call, the dance of death. My research now focuses on understanding the impact of this process during infectious disease and cancer.

Feature publications

Monocyte apoptotic bodies are vehicles for influenza A virus propagation

A novel mechanism of generating extracellular vesicles during apoptosis via beads-on-a-string...

A novel mechanism of generating extracellular vesicles during apoptosis via beads-on-a-string...

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Atkin-Smith GK, Duan M, Zanker DJ, Loh L, Nguyen THO, Koutsakos M, Nguyen T, Jiang X,  Carrera J, Phan TK, Liu C, Paone S, Oveissi S, Hodge AL,  Baxter AA, Kedzierska K, Mackenzie JM, Hulett MD, Bilsel P, Chen W & Poon IKH Communications Biology

8 May 2020

see paper

A novel mechanism of generating extracellular vesicles during apoptosis via beads-on-a-string...

A novel mechanism of generating extracellular vesicles during apoptosis via beads-on-a-string...

A novel mechanism of generating extracellular vesicles during apoptosis via beads-on-a-string...

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 Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD & Poon IKH

Nature Communications

15 June 2015

see paper

Full publication list

Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance

Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies...

Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance

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Santavanond J, Rutter SF, 

Atkin-Smith GK*, Poon IKH*

Subcellular Biochemistry (Book, *co-senior)

New Frontiers: Extracellular Vesicles 

29 March 2020

See chapter

Plexin B2 is a novel regulator of monocyte apoptotic cell disassembly

Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies...

Apoptotic Bodies: Mechanism of Formation, Isolation and Functional Relevance

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Atkin-Smith GK, Miles MA, Tixeira R, Lay FT, Duan M, Hawkins CJ, Phan TK, Paone S, Mathivanan S, Hulett MD, Chen W & Poon IKH

Cell Reports

21 Nov 2019

see paper

Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies...

Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies...

Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies...

image53

Caruso S*, Atkin-Smith GK*, Baxter AA, Tixeria R, Jiang L, Ozkocak DC, Santavanond JP, Hulett MD, Lock P, Phan TK & Poon IKH

Apoptosis

05 Sep 2019

see paper

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

Defining the role of cytoskeletal components in the formation of apoptopodia and apoptotic bodies...

image54

Tixeira R, Phan TK, Caruso S, Shi B, 

Atkin-Smith GK, Nedeva C, Chow JDY, Puthalakath H, Hulett MD, Herold MJ & Poon IKH 

Cell Death & Differentiation

01 May 2019

see paper

Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-...

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement...

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Poon IKH, Parkes MAF, Jiang L, Atkin-Smith GK, Tixeira R, Gregory C, Ozkocak DC, Rutter SF, Caruso S, Santavanond JP, Paone S, Shi B, Hodge AL, Hulett MD, Chow JDY, Phan TK & Baxter AA 

Journal of Extracellular Vesicles

26 April 2019

see paper

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement...

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement...

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Thery C, Witwer KW, …Atkin-Smith GK et al.

Journal of Extracellular Vesicles

03 March 2016

see paper

The induction and consequences of Influenza A virus-induced cell death

​Determining the contents and cell origins of apoptotic bodies by flow cytometry

The induction and consequences of Influenza A virus-induced cell death

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Atkin-Smith GK*, Duan M*, Chen W & Poon IKH*
Cell Death and Disease
25 September 2018
(*Co-senior)

see paper

Detection and isolation of apoptotic bodies to high purity

​Determining the contents and cell origins of apoptotic bodies by flow cytometry

The induction and consequences of Influenza A virus-induced cell death

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Phan TK, Poon IKH & Atkin-Smith GK
Journal of Visualized Experiments
12 August 2018

(Senior author)

see paper

​Determining the contents and cell origins of apoptotic bodies by flow cytometry

​Determining the contents and cell origins of apoptotic bodies by flow cytometry

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting

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Jiang L, Paone S, Caruso S, Atkin-Smith GK, Phan TK, Hulett MD & Poon IKH
Scientific Reports
31 October 2017

see paper

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting

​Monitoring the progression of cell death and disassembly of dying cells by flow cytometry

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting

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Atkin-Smith GK, Paone S, Zanker DJ, Duan M, Phan TK, Chen W, Hulett MD & Poon IKH
Scientific Reports
06 January 2017

see paper

Defining the morphologic features and products of cell disassembly during apoptosis

​Monitoring the progression of cell death and disassembly of dying cells by flow cytometry

​Monitoring the progression of cell death and disassembly of dying cells by flow cytometry

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Tixeia R, Caruso S, Paone S, Baxter AA, 

Atkin-Smith GK, Hulett MD & Poon IKH
Apoptosis
19 January 2017

see paper

​Monitoring the progression of cell death and disassembly of dying cells by flow cytometry

​Monitoring the progression of cell death and disassembly of dying cells by flow cytometry

​Monitoring the progression of cell death and disassembly of dying cells by flow cytometry

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Jiang L, Tixeira R, Caruso S, Atkin-Smith GK, Baxter AA, Hulett MD, Paone S and Poon IKH
Nature Protocols
03 March 2016

see paper

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