The dance of death

Everyday billions of cells within the human body will die through a regulated type of cell death known as apoptosis. By using time-lapse imaging, we recently discovered that monocytes, key white blood cells of the immune system, undergo an explosive cell death by forming long structures we termed beaded-apoptopodia. The what, how and why then became the underlining questions of my research.

Publications

The induction and consequences of Influenza A virus-induced cell death

Atkin-Smith GK#, Duan M#, Chen W & Poon IKH#

Cell Death and Disease

25 September 2018

#: Co-corresponding

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Detection and isolation of apoptotic bodies to high purity

 Phan TK, Poon IKH & Atkin-Smith GK

Journal of Visualized Experiments

12 August 2018

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​Determining the contents and cell origins of apoptotic bodies by flow cytometry

Jiang L*, Paone S*, Caruso S, Atkin-Smith GK, Phan TK, Hulett MD & Poon IKH

Scientific Reports

31 October 2017

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Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting

Atkin-Smith GK*, Paone S*, Zanker DJ, Duan M, Phan TK, Chen W, Hulett MD & Poon IKH

Scientific Reports

06 January 2017

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​Defining the morphologic features and products of cell disassembly during apoptosis

Tixeia R*, Caruso S*, Paone S, Baxter AA, Atkin-Smith GK, Hulett MD & Poon IKH

Apoptosis

19 January 2017

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​Monitoring the progression of cell death and disassembly of dying cells by flow cytometry

Jiang L*, Tixeira R*, Caruso S, Atkin-Smith GK, Baxter AA, Hulett MD, Paone S and Poon IKH

Nature Protocols

03 March 2016

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A novel mechanism of generating extracellular vesicles during apoptosis via beads-on-a-string...

 

Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD & Poon IKH

Nature Communications

15 June 2015

see paper